I found this article
http://www.lhc.org.uk/members/pubs/books/vdu/vd02.htm
Here is a brief excerpt from that page
Whenever possible, jobs at display screen should be designed to consist of a mix of screen-based and non screen-based work to prevent fatigue and to vary visual and mental demands. Where the job unavoidably contains spells of intensive display screen work these should be broken up by periods of non-intensive, non-display screen work. Where work cannot be so organised, eg in jobs requiring only data or text entry requiring sustained attention and concentration, deliberate breaks or pauses must be introduced.
Regulation 4 Guidance note 43
Breaks should be taken before the onset of fatigue, not in order to recuperate.
Regulation 4 Guidance note 45 (a)
Breaks or changes of activity should be included in working time. They should reduce the workload at the screen, ie should not result in a higher pace or intensity of work on account of their introduction.
Regulation 4 Guidance note 45 (b)
Short, frequent breaks are more satisfactory than occasional, longer breaks: eg, a 5-10 minute break after 50-60 minutes continuous screen and/or keyboard work is likely to be better than a 15 minute break every two hours.